Cancer Immunotherapy

cancer-cells

“AIVITA’s approach aims to use the patient’s own immune system to seek out and destroy cancer cells, including the tumor-initiating cells that are responsible for the growth and spread of the disease.”

Overview

AIVITA’s immunotherapy technology creates personalized vaccines for cancer patients that target and eliminate tumor-initiating cells which are the seed of the disease. Used alone or in parallel with other treatments, AIVITA’s cancer immunotherapy represents a powerful new approach in the search for curative treatments for cancer.

The Advantage of AIVITA's Approach

The advantage of AIVITA’s approach lies in our pan-antigenic approach – targeting all neoantigens, rather than a select few – to train the patient’s immune system to target tumor-initiating cells. By educating immune cells isolated from the patient’s own blood to recognize the complete and unique antigenic signature of the patient’s own cancer-initiating cells, the treatment is capable of seeking out and destroying cancer and overcoming mutations over time.

In addition, by exposing the patient’s immune system to a broader spectrum of antigens represented in the patient’s own cancer, it is believed that the patient’s immune system will now be able to identify mutated or dormant tumor-initiating cells.

AIVITA Biomedical is working to identify a surrogate, predictive marker of efficacy and is developing a potency assay for predictive analysis.

AIVITA Biomedical’s cancer immunotherapy technology is based on recent discoveries indicating that tumor growth and metastasis are primarily driven by tumor-initiating cells. Tumor-initiating cells represent a small portion of the mass of a typical tumor but are the most prolific in their ability to generate additional cancer cells. Acting as the engines of the disease, tumor-initiating cells are responsible for the growth and eventual spread of cancer through the patient’s body.

Cancer immunotherapies aim to teach the host’s own immune system how to seek out specific antigens associated with cancer to destroy it wherever it has spread. AIVITA’s patient-specific approach utilizes the complete and unique antigenic signature of the patient’s own tumor. AIVITA believes this proprietary process provides the immune system with a fuller range of antigens specific to each patient’s own cancer.

AIVITA Biomedical’s cancer immunotherapy technology consists of autologous dendritic cells loaded with antigens derived from autologous tumor-initiating cells. The therapy is administered through a series of subcutaneous injections.

Development of the therapy begins when a sample of the patient’s surgically resected tumor is shipped to AIVITA Biomedical’s facilities. Cell culture allows for the enrichment and amplification of live tumor-initiating cells, both for the quantitative enhancement of the tumor- associated antigens and for the depletion of misleading signals that could interfere with the immunogenic process, such as dead cells, normal cells, and extracellular matrix. Using this approach, the patient’s tumor-initiating cells are enriched and become the target of AIVITA’s immunotherapeutic approach.

Through a process of blood filtration known as leukapheresis, antigen-presenting dendritic cells are derived from the patient’s blood. Dendritic cells, often referred to as the messenger cells of the immune system, are responsible for identifying foreign (non-self) antigens and presenting them as targets to the immune system. Using this to our advantage, we load the patient’s dendritic cells with the patient’s own tumor-associated antigens, priming them with the full antigenic signature.

Other approaches using a limited number of antigens, or those that attempt to prime dendritic cells in the presence of all tumor cells, have not shown sufficient efficacy to be meaningful cancer treatments. AIVITA’s approach primes the immune system more effectively to recognize the unique antigenic signature of the patient’s own seed of cancer, the tumor-initiating cells. Additionally, having educated the immune system to recognize tumor-initiating cells, AIVITA believes that any dormant cells which become active at a later time point will be similarly destroyed by the patient’s immune system.

Once prepared, the treatment is administered in a series of subcutaneous injections.

  • • Pan-antigenic: Presents the immune system with multiple neoantigens from the patient’s own tumor-initiating cells, rather than targeting a limited number of antigens
  • Targeting the seed: Targets and destroys tumor-initiating cells responsible for the growth and spread of the disease
  • Patient-friendly: Minimally invasive subcutaneous injections and a non-toxic approach to treating cancer
  • Comprehensive: Utilizes innate and adaptive immune functions, with the potential to find and destroy cancer wherever it has spread

AIVITA currently has an active Phase 2 trial investigating its cancer vaccine in patients with ovarian cancer. Details of the trial can be found at Clinicaltrials.gov, under trial identifier NCT02033616.
AIVITA currently has an active Phase 2 trial investigating its cancer vaccine in patients with glioblastoma. Details of the trial can be found at Clinicaltrials.gov, under trial identifier NCT03400917.
AIVITA has received IND approval to begin a Phase 1 trial investigating its cancer vaccine in patients with metastatic melanoma plus checkpoint inhibitors. Details of the trial can be found at Clinicaltrials.gov, under the trial identifier NCT03743298.